|First appearance||Marvel Universe Avenger Earth Mightiest Heroes #2|
The Zodiac is a criminal cartel bent on world domination. It consists of twelve members, which are based on the Zodiac symbols.
- The members who have yet to make an appearance include Aries, Cancer, Capricorn, Libra, Pisces and Virgo.
- The Zodiac were the primary antagonists (after Ultron) of a previous Avengers television series: The Avengers: United They Stand.